Statistical
Methods for Computational Biology
BCB/GEN 557 Spring 2004
Instructor: Xun Gu
Office: 322 Science II Hall
Email: xgu@iastate.edu
Office hour: by appointment
Lectures: TR 3:40 - 5:00, Town 0230.
Textbook: Molecular Evolution and Phylogenetics.
Masatoshi Nei, Sudhir Kumar, OXFORD University Press 2000
Web
Page: http://xgu.zool.iastate.edu
Grading
Homework assignments and Discussion (25%)
Term-paper (literature-review) (40%)
Presentation (35%)
Time
Schedule
Presentation Schedule:
Apr. 15(Thur): Since
nobody will give presentation today, so no class.
Apr. 20(Tues): Scott
Emrich; Wu Di; Zhongqi Zhang.
Apr. 22(Thur): Michael
Sparks; Wei Huang; Ying Zheng.
Apr.
27(Tues): Ding Jing; Kalyan Dudala.
Reading
Papers:
[1]
Gu X (1999) Statistical methods for testing functional divergence
after gene duplication. Molecular Biology and Evolution
16:1664-1674.
[2] Gu X (2001) Maximum likelihood approach for gene family
evolution under functional divergence. Molecular Biology
and Evolution. 18: 453-464.
[3] Wang Y, Gu X (2001) Functional divergence in the Caspase
gene family and altered functional constraints: statistical analysis
and prediction. Genetics. 158:1311-1320.
[4] Gu J, Gu X (2003) Induced gene expression in human brain
after the split from chimpanzee. TRENDS in Genetics. 19:63-65.
[5] Gu J, Gu X (2003) Further statistical analysis for genome-wide
expression evolution in primate brain/liver/fibroblast tissues.
Human Genomics. |
